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NEWS


  • Award-winning collaborative work

  • News 1

  • The Chair of Biotechnology at the LGPM laboratory and the Chair of Photonics at the LMOPS laboratory (CentraleSupélec and University of Lorraine) are collaborating to develop a real-time spectroscopic analysis sensor for monitoring alcoholic fermentation. The complementary skills of the two teams (from Pomacle and Metz), in biotechnology and spectroscopy/photonics, have just given very promising initial results, allowing several parameters to be monitored during alcoholic fermentation. These results were obtained using laser technology based on the Raman effect.

    The quality of the work carried out within the framework of this project has been rewarded by the scientific community: the prize for the best poster of the conference of the French Group of Vibration Spectroscopy (from 13 to 15 May 2019 in Lyon) was awarded to Victor Colas, intern supervised by the two CentraleSupélec sites.

    This sensor can be applied in any industrial field related to fermentation in order to better understand and control the fermentation process. It will allow real-time analysis to be carried out without contact and without risk of product contamination.

    The Chair of Biotechnology thanks its funders, the Conseil départemental de la Marne, Grand Reims and the Région Grand Est. The Photonics Chair benefits from the financial support of AIRBUS - GDI Simulation, the European Union (ERDF), the Ministry of Higher Education and Research, the Grand Est Region, the Moselle Department and Metz Métropole.
  • 3D printed photobioreactor

  • News 1

  • The Chair of Biotechnology has just product its first miniphotobioreactor entirely realized thanks to 3D printing. Its design comes from a fully digital procedure, carried out internally. Its realization is the fruit of the know-how in 3D printing and prototyping of our colleagues of La Fabrique. The light supply in large scale bioreactors is a major industrial bottleneck. We develop tools to offer new solutions. For this purpose, we study the reaction of microalgae to specific light cycles.

    Such work can not be carried out in any type of reactor. We have designed ours to ensure that each cell that composes the culture receives the same amount of light. The perspectives opened by this work are vast: from the increase of the raw biomass production for use in food and feed, to the intensification of the production of pigments.
  • Installation of a GC-MS/MS for lipid analysis

  • News 1

  • As part of the Interreg IDEA project, the Chair of Biotechnology has just acquired a gas chromatograph coupled with a triple quadrupole mass spectrometer (GC-MS/MS), a GC-2010 Plus model and a TQ-8040 from Shimadzu.

    This device is used to identify and quantify fatty acids from microalgae. Fatty acids, which are a sub-family of lipids, are among the high value-added compounds that microalgae can produce, including polyunsaturated fatty acids such as omega-3 and omega-6, which are necessary for human nutrition.

    Gas chromatography is a technology that allows the separation of different fatty acids and their isomers. Coupling with mass spectrometry makes it possible to identify these compounds and quantify them not only major compounds but also minor compounds with concentrations down to 10 µg/L.

WHO ARE WE?

The Chair of Biotechnology of CentraleSupélec, launched in 2010 and located in the Centre Européen de Biotechnologie et de Bioéconomie (CEBB), has three areas of expertise:

  • Characterization & conversion of lignocellulosics,
  • Biotransformation,
  • Downstream processing.

Backed by the Process Engineering and Materials Laboratory, this chair is a strong link between its head institution – CentraleSupélec – and economic and academic actors; most of the R&D activities are led in regional, national and international collaborative projects. With its training of high-level general engineers, CentraleSupélec has a strong expertise in modeling applied to (bio)process and (bio)materials. Thus, in addition to the experimental approach, the three areas of expertise of the Chair significantly rely on a set of core skills in Modeling, Simulation & Visualization, more particularly oriented towards the modeling of life mechanisms and the up-scaling of processes for the industry.

Our brochure in English.

EXPERTISE AREAS

  • Characterization and conversion of lignocellulosics track

  • Axe 1

  • Our advanced characterization techniques are applied to the study of the physico-mechanical properties of lignocellulosic materials (3D-BioMat project). They are involved in both the optimization of pretreatment processes for energy and the design of innovative bio-based materials.
  • Biotransformation track

  • Axe 2

  • CentraleSupélec’s long standing expertise in process engineering is applied to biotransformation with the aim of producing high-value compounds, processing industrial effluents or system optimization for growth control and new (photo)bioreactor design.
  • Separation techniques track

  • Axe 3

  • Our vocation is to develop effective, sober and sustainable separation processes to extract and purify biosourced molecules. In addition, we offer solutions for upgrading industrial effluents and co-products (lignocellulose, pentoses, biogas, etc.).

OUR FLAGSHIP EQUIPMENTS


Equipement 1

Chromatography is the core of our analytical platform. UHPLC, HPLC, IC and GC technologies, coupled with RI, FLD, UV, MS and Orbitrap detectors, and supplemented by ICP-OES, AAS and CHNS/O analyzers allow to identify and quantify a wide range of organic and inorganic compounds. In addition, cell counter and RT-qPCR are used for monitoring cell cultures.

  • Our key equipments:
  • HPLC
  • Gas chromatography
  • qPCR
  • Cell counter

Analytical platform

Bleeding edge equipments to better analyze and valorize bioressources

Chromatography is the core of our analytical platform. UHPLC, HPLC, IC and GC technologies, coupled with RI, FLD, UV, MS and Orbitrap detectors, and supplemented by ICP-OES, AAS and CHNS/O analyzers allow to identify and quantify a wide range of organic and inorganic compounds. In addition, cell counter and RT-qPCR are used for monitoring cell cultures.

Equipement 2

The upscaling of separation processes is based on a fleet of laboratory pilots, located in a dedicated hall: ultra-, nano-filtration and reverse osmosis, conventional and bipolar electrodialysis, preparative chromatography, continuous ion exchange and gas-liquid absorption with membrane contactors.

  • Our key equipments:
  • Ultra- and nano-filtrations
  • Reverse osmosis and electrodialysis
  • Preparative chromatography
  • Membrane contactors

Laboratory pilots fleet

A link to secure the transfer of innovation to industry

The upscaling of separation processes is based on a fleet of laboratory pilots, located in a dedicated hall: ultra-, nano-filtration and reverse osmosis, conventional and bipolar electrodialysis, preparative chromatography, continuous ion exchange and gas-liquid absorption with membrane contactors.


Equipement 3

The Chair of Biotechnology possesses of a considerable range of equipment adapted for the culture, analysis and treatment of microscopic cell (plant, bacteria, yeasts and fungi as well as microalgae). The cultures can be grown at different scales: petri-dish, shake-flask, 2-20 L (photo)bioreactor. In addition to the 20 L pilot-scale bioreactor, a fully automated 30 L raceway pond allows the initial stages of scale-up of photosynthetic cultures.

  • Our key equipments:
  • Bioreactors
  • Photobioreactors
  • Raceway ponds
  • Incubators

Growth systems

The biological factory aiming to produce high added-value molecules

The Chair of Biotechnology possesses of a considerable range of equipment adapted for the culture, analysis and treatment of microscopic cell (plant, bacteria, yeasts and fungi as well as microalgae). The cultures can be grown at different scales: petri-dish, shake-flask, 2-20 L (photo)bioreactor. In addition to the 20 L pilot-scale bioreactor, a fully automated 30 L raceway pond allows the initial stages of scale-up of photosynthetic cultures.

Equipement 4

Diagnosis, quantitative analysis and modeling on real morphology with temporal evolution rely on the imagery platform. Our X-ray nano-tomograph, microscopes (confocal, Raman ESEM) and structured illumination macroscope allow the acquisition of high-resolution images in 2D, 3D and 4D that are compatible with digital post-processing.

  • Our key equipments:
  • Xray nano-tomograph
  • Raman microscops
  • Confocal microscope
  • SEM

Imagery platform

Observe what is infinity small to optimize industrial processes

Diagnosis, quantitative analysis and modeling on real morphology with temporal evolution rely on the imagery platform. Our X-ray nano-tomograph, microscopes (confocal, Raman ESEM) and structured illumination macroscope allow the acquisition of high-resolution images in 2D, 3D and 4D that are compatible with digital post-processing.

Contact

Address

Centre Européen de Biotechnologie et de Bioéconomie
3, rue des Rouges Terres
51110 Pomacle, France

GPS : 49.346017, 4.156493

E-mail

chaire-biotechnologie@centralesupelec.fr

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Institutional partners

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